May 10, 2019 Extraskeletal osteosarcoma. Strong and diffuse nuclear expression of SATB2 supports a morphologic diagnosis of osteogenic malignancy.

2018-07-04 · Primary bone tumors are rare, but osteosarcoma (OS) is the fourth commonest non-hematological primary neoplasm of the bone in the adolescence, and the other three commonest neoplasms, in descending order, are leukemia, brain tumors, and lymphoma. The commonest presenting complaints are swelling and aches. These tumors cannot be diagnosed without the help of radiology. There is a wide age range

High SATB2 expression in osteosarcoma patient samples was associated with poor clinical outcome. N-cadherin was one critical downstream target gene of SATB2 that mediated the stem cell-like phenotype. Reduction of SATB2 or N-cadherin resulted in NF-kB inactivation, which led to impaired osteosarcoma sphere formation and tumor cell proliferation. SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours.

This is the first report, where we have documented the increased expression of SATB2-AS1 in osteosarcoma patients and in human osteosarcoma cancer cell lines (U2OS, HOS, MG63). SATB2-AS1 expression was significantly higher in the metastatic tumors compared to non-metastatic tumors. 1. SATB2 enhances migration and invasion in osteosarcoma. (5,37) 2.

SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of

Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some 2019-07-05 · 1. Anticancer Agents Med Chem.

SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid.

2020-11-04 · SATB2 is an immunohistochemical marker for osteoblast differentiation. Our aim was to investigate SATB2 expression in oral osteosarcoma and other bone producing oral tumors/reactive lesions to evaluate its usefulness as a diagnostic marker. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid.

Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid. SATB2, strongly expressed in oral osteosarcoma, fibroosseous lesions, and central giant cell granuloma, is not a reliable diagnostic marker. However, SATB2 can distinguish between induced neoplastic bone and reactive bone tissue. Targeting SATB2 as an alternative therapy should be investigated.
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doi: 10.2174/1871520619666190705121614. [Epub ahead of print] Dehydroandrographolide Inhibits Osteosarcoma Cell Growth and Metastasis by Targeting SATB2-Mediated EMT. CONCLUSIONS: SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth. The combination of conventional chemotherapy and metformin may be a promising therapeutic strategy for os-teosarcoma patients. Key Words: Cancer stem cells, Chemoresistance, Metformin, N-cadherin, Osteosarcoma, SATB2, Tumorigenesis.

There is a wide age range positive for SATB2, and 2 SATB2–negative cases were positive for CDH-17. Therefore, CDH-17 and SATB2 are complementary and, when used together, could identify all MC.5 IV. Other markers available for detection of metastatic CRC Dragomir, et al reports that SATB2 marker alone had 93% sensitivity and 77% specificity in determining CRC. Small round cell osteosarcoma is a very rare type of osteosarcoma, histologically mimicking other small round cell malignancies of bone, most notably Ewing sarcoma. To distinguish small cell osteosarcoma from other primary small cell malignancies of bone, we evaluated the immunohistochemical (IHC) expression of CD99 and SATB2, a marker of osteoblastic differentiation. Feb 11, 2021 Bone - Osteosarcoma - general.
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Mar 26, 2019 The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such

Learn about bone cancer and find information on how we care for people with Apr 15, 2021 Osteosarcoma and undifferentiated pleomorphic sarcoma (UPS) (formerly called malignant fibrous histiocytoma [MFH]) of bone treatment av C Lindskog Bergström · 2013 · Citerat av 1 — and SATB2) proved to be significantly differentially expressed on the tumor suppressor, down-regulated in e.g.

SATB2 showed 100% sensitivity (10/10) and 60% (6/10) specificity in discriminating classic osteosarcoma from osteosarcoma mimics. Utilizing negative SATB2 as a surrogate marker to exclude osteosarcoma, 73% (16/22) of the reviewers would have downgraded at least 1 case to not contain an osteosarcomatous component (range, 1-6 cases, median 1 case).

Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of bone, for instance Ewing sarcoma family of tumors (ESFT), it has not been tested in a large series of ESFT and chondrosarcomas so far. SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth. The combination of conventional chemotherapy and metformin may be a promising therapeutic strategy for osteosarcoma patients. 2020-11-04 · SATB2 is an immunohistochemical marker for osteoblast differentiation.

Am J Clin Pathol. 2014 May;141(5):630-8. doi: 10.1309/AJCPWW2URZ9JKQJU.